<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-13749" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2026-06-09</depositionDate>
            <releaseDate>2026-07-10</releaseDate>
            <updateDate>2026-07-10</updateDate>
        </keyDates>
        <title>Cryo Electron Microscopy micrographs of multidrug resistance-associated protein 2 (MRP2) EQ Mutant bound to ATP</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0003-2075-4283</authorORCID>
            <firstName>Jue</firstName>
            <lastName>Chen</lastName>
            <organization type="academic">Rockefeller University, Howard Hughes Medical Institute</organization>
            <street>1230 York Ave</street>
            <townOrCity>New York</townOrCity>
            <stateOrProvince>NY</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>10065</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0003-2075-4283</authorORCID>
            <firstName>Jue</firstName>
            <lastName>Chen</lastName>
            <organization type="academic">The Rockefeller University, Howard Hughes Medical Institute</organization>
            <street>1230 York Ave</street>
            <townOrCity>New York</townOrCity>
            <stateOrProvince>New York</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>10065</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0002-8289-1542">Koide EK</author>
            <author authorORCID="0000-0003-4792-5708">Pietz HLP</author>
            <author>Beltran JB</author>
            <author authorORCID="0000-0003-2075-4283">Chen JC</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>Howard Hughes Medical Institute (HHMI)</fundingBody>
                <code>N/A</code>
                <country>United States</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">4.0</datasetSize>
        <entryDOI>10.6019/EMPIAR-13749</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-44911</emdbEntry>
            <emdbEntry>EMD-44833</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0002-8289-1542" order="1">Koide EK</author>
                    <author authorORCID="0000-0003-4792-5708" order="2">Pietz HLP</author>
                    <author order="3">Beltran JB</author>
                    <author authorORCID="0000-0003-2075-4283" order="4">Chen JC</author>
                    <title>Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2</title>
                    <journal>Nature Communications</journal>
                    <journalAbbreviation>Nat Commun</journalAbbreviation>
                    <country>United States</country>
                    <issue>16</issue>
                    <volume>484</volume>
                    <year>2025</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41467-024-55810-w</externalReferences>
                    <externalReferences type="pubmed">39779684</externalReferences>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Cryo Electron Microscopy micrographs of multidrug resistance-associated protein 2 (MRP2) EQ Mutant bound to ATP</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>7532</numImagesOrTiltSeries>
        <framesPerImage>50</framesPerImage>
        <voxelType>UNSIGNED 16 BIT INTEGER</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.676</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.676</pixelHeight>
        </dimensions>
        <details>This dataset contains gain-corrected movies of the multidrug resistance-associated protein 2 (MRP2) E1462Q mutant bound to ATP. The pixel size is 0.676 Angstrom. This dataset corresponds to both the inward-facing and outward-facing ATP-bound structures (EMD-44833 and EMD-44911).</details>
        <segmentationList/>
        <micrographsFilePattern>data/20220909_hMRP2_EQ_219_*.tif</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
