REL 2026-05-16 2026-06-10 2026-06-10 Engineered nanobody 1G1 bound to the acidic patch of the nucleosome 0000-0001-9195-2282 Jean-Paul Armache Department of Biochemistry and Molecular Biology, Pennsylvania State University 428 South Frear Lab University park Pennsylvania United States 16802 0000-0001-9195-2282 Jean-Paul Armache Department of Biochemistry and Molecular Biology, Pennsylvania State University 428 South Frear Lab University Park Pennsylvania United States 16802 Jean-Paul Armache Pennsylvania State University University Park United States 16802 0000-0002-2219-8623 Michael-Christopher Keogh EpiCypher Inc. 6 Davis Dr Durham North Carolina United States 27709 0000-0001-9765-1659 Jessica K Tyler Department of Pathology and Laboratory Medicine, Weill Cornell Medicine 1300 York Avenue New York New York United States 10065 Chakraborty U Saccone EC Becerra GC Khan LF Arslanovic N Aguilar R Gloor SL Hunt SR Folkwein HJ Husby NL Maier KE Marunde MR Schomburg NK Vaidya A Cowles MW Venters BJ Kassavetis G Sun ZW Kadonaga JT Armache JP Keogh MC Tyler JK National Institutes of Health (NIH) R44HG010640 United States National Institutes of Health (NIH) R44GM117683 United States National Institutes of Health (NIH) R44GM136172 United States National Institutes of Health (NIH) R44CA212733 United States National Institutes of Health (NIH) R43GM134834 United States National Institutes of Health (NIH) R35GM118060 United States National Institutes of Health (NIH) R35GM139816 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R35GM161751 United States 4.0 10.6019/EMPIAR-13564 EMDB molecule EMD-74114 Chakraborty U Saccone EC Becerra GC Khan LF Arslanovic N Aguilar R Gloor SL Hunt SR Folkwein HJ Husby NL Maier KE Marunde MR Schomburg NK Vaidya A Cowles MW Venters BJ Kassavetis G Sun ZW Kadonaga JT Armache JP Keogh MC Tyler JK Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes United States Unaligned multi-frame images of the nucleosome-bound nanobody 1G1 bound to the nucleosome /data/RawData/NCEF-088-026-00749-A micrographs - multiframe TIFF TIFF 8302 40 1 40 UNSIGNED BYTE 11520 0.549 8184 0.549
data/RawData/NCEF-088-026-00749-A/20250616_????_A???_G???_H???_D0??.tiff Motion-corrected and dose-weighted summed micrographs /data/MotionCorrected micrographs - single frame MRC MRC 8302 40 1 40 UNSIGNED 32 BIT INTEGER 5760 1.098 4092 1.098
data/MotionCorrected/NCEF-088-026-00749-A/20250616_????_A???_G???_H???_D0??.mrc