REL
2026-03-19
2026-06-01
2026-06-01
An auto inhibitory loop in the MiDAC histone deacetylase complex
0000-0001-9456-3047
Louise
Fairall
Institute of Structural and Chemical Biology, University of Leicester
Lancaster Road
Leicester
Leicestershire
United Kingdom
LE1 7RP
0000-0003-2865-4383
John
WR
Schwabe
Institute of Structural and Chemical Biology, University of Leicester
Lancaster Road
Leicester
Leicestershire
United Kingdom
LE1 7RH
Fairall L
Schwabe JWR
Wellcome Trust
222493/Z/21/Z
United Kingdom
2.3
10.6019/EMPIAR-13539
EMDB
molecule
EMD-53563
EMD-53564
EMD-53565
EMD-53566
EMD-53567
Fairall L
Sirvydis K
Turnbull RE
Knottnerus SJ
Gonchar O
Muskett FW
Jukes-Jones R
van Brussel L
van de Geer E
van Gassen K
Badenhorst P
Johnson D
Terhal PA
van Hasselt PM
van Jaarsveld RH
Schwabe JW
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome
Nature communications
Nat Commun
1
16
10472
10472
2025
English
10.1038/s41467-025-65472-x
41290615
Raw images
Micrographs for MiDAC and nucleosome
/data
micrographs - multiframe
TIFF
TIFF
11093
50
1
50
SIGNED BYTE
5760
0.835
4092
0.835