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            <depositionDate>2026-04-16</depositionDate>
            <releaseDate>2026-04-24</releaseDate>
            <updateDate>2026-04-24</updateDate>
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        <title>Filament of D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-2661-8226</authorORCID>
            <firstName>Peng</firstName>
            <lastName>Ge</lastName>
            <organization type="academic">Department of Biological Chemistry, UCLA</organization>
            <townOrCity>Los Angeles</townOrCity>
            <stateOrProvince>California</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>90095</postOrZipCode>
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            <firstName>David</firstName>
            <middleName>S</middleName>
            <lastName>Eisenberg</lastName>
            <organization type="academic">Department of Chemistry and Biochemistry, and Department of Biological Chemistry, UCLA; HHMI</organization>
            <townOrCity>Los Angeles</townOrCity>
            <stateOrProvince>California</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>90095</postOrZipCode>
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        <authorsList>
            <author authorORCID="0000-0003-3869-2076">Hou K</author>
            <author authorORCID="0000-0002-2661-8226">Ge P</author>
            <author>Zhang J</author>
            <author>Lu J</author>
            <author>Abskharon R</author>
            <author authorORCID="0000-0002-9794-7537">Yang S</author>
            <author authorORCID="0000-0002-7114-2570">Yu Z</author>
            <author authorORCID="0000-0003-3376-435X">Feigon J</author>
            <author authorORCID="0000-0003-2432-5419">Eisenberg DS</author>
            <author authorORCID="0000-0003-0874-9043">Sawaya MR</author>
            <author>Lutter L</author>
            <author authorORCID="0000-0002-8042-9645">Dolinsky JL</author>
            <author authorORCID="0000-0002-9538-6369">Yang Y</author>
            <author authorORCID="0000-0003-1433-4952">Jiang YX</author>
            <author authorORCID="0000-0002-4487-0230">Boyer DR</author>
            <author authorORCID="0000-0003-1654-4363">Cheng X</author>
            <author authorORCID="0009-0000-9956-6351">Pi J</author>
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                <country></country>
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        <entryDOI>10.6019/EMPIAR-13499</entryDOI>
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        <scale>molecule</scale>
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    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-44182</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0003-3869-2076" order="1">Hou K</author>
                    <author authorORCID="0000-0002-2661-8226" order="2">Ge P</author>
                    <author authorORCID="0000-0003-0874-9043" order="3">Sawaya MR</author>
                    <author order="4">Lutter L</author>
                    <author authorORCID="0000-0002-8042-9645" order="5">Dolinsky JL</author>
                    <author authorORCID="0000-0002-9538-6369" order="6">Yang Y</author>
                    <author authorORCID="0000-0003-1433-4952" order="7">Jiang YX</author>
                    <author authorORCID="0000-0002-4487-0230" order="8">Boyer DR</author>
                    <author authorORCID="0000-0003-1654-4363" order="9">Cheng X</author>
                    <author authorORCID="0009-0000-9956-6351" order="10">Pi J</author>
                    <author order="11">Zhang J</author>
                    <author order="12">Lu J</author>
                    <author order="13">Abskharon R</author>
                    <author authorORCID="0000-0002-9794-7537" order="14">Yang S</author>
                    <author authorORCID="0000-0002-7114-2570" order="15">Yu Z</author>
                    <author authorORCID="0000-0003-3376-435X" order="16">Feigon J</author>
                    <author authorORCID="0000-0003-2432-5419" order="17">Eisenberg DS</author>
                    <title>How short peptides disassemble tau fibrils in Alzheimer's disease</title>
                    <journal>Nature</journal>
                    <journalAbbreviation>Nature</journalAbbreviation>
                    <country></country>
                    <issue>8078</issue>
                    <volume>644</volume>
                    <firstPage>1020</firstPage>
                    <lastPage>1027</lastPage>
                    <year>2025</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41586-025-09244-z</externalReferences>
                    <externalReferences type="pubmed">40634605</externalReferences>
                    <details>TIFF movies. Total dosage is 50 e/A2. Gain reference provided.</details>
                </journalCitation>
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        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>5192</numImagesOrTiltSeries>
        <framesPerImage>40</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
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            <pixelWidth>0.5335</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.5335</pixelHeight>
        </dimensions>
        <details>Dosage per frame is 1.5 e-/A2. Use n22oct31f_31110844_01_8184x11520_norm_0.mrc as gain reference.</details>
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        <micrographsFilePattern>data/n22oct31*.tif</micrographsFilePattern>
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