REL 2026-03-17 2026-05-23 2026-05-23 Cryo electron microscopy of human SCFbxo22 in complex with protacs, neosubstrates and endogeneous substrates. 0000-0002-5018-1941 Sascha Josef Amann IMP Vienna Austria 1030 0000-0002-5276-5633 David Haselbach IMP Vienna Austria 1030 0000-0002-6141-0164 Nicholas Gene Brown UNC Chapel Hill United States 27599 Amann SJ Robertson KC Liu T James LI Brown NG Haselbach D 4.5 10.6019/EMPIAR-13495 EMDB molecule EMD-57178 EMD-57179 EMD-57180 Robertson KC Amann SJ Liu T Funk AV Wang X Grishkovskaya I Mehmood A Tabor JR Norris-Drouin JL Arrowsmith CH Collins JL Miao Y Emanuele MJ Haselbach D James LI Brown NG Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 Nature communications Nat Commun 2026 English 10.1038/s41467-026-72235-9 42026065
The micrographs are the average of aligned .eer files, accumulating 50 electron per square Angstrom.
 Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088 /data/scf_unc10088_nsd2 micrographs - single frame MRC MRC 48007 1 32 BIT FLOAT 4096 0.951 4096 0.951
Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088
 Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088 and BACH1 /data/scf_unc10088_nsd2_bach1 micrographs - single frame MRC MRC 29805 1 16 BIT FLOAT 4096 0.951 4096 0.951
Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088 and BACH1
 Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10415667 /data/scf_unc10415667_nsd2 micrographs - single frame MRC MRC 30020 1 16 BIT FLOAT 4096 0.951 4096 0.951
Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10415667