Cryo electron microscopy of amyloid fibrils of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer’s disease tau fibrils

REL 2025-04-16 2026-03-09 2026-03-09 Cryo electron microscopy of amyloid fibrils of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer’s disease tau fibrils 0000-0003-1433-4952 Yi Xiao Jiang University of California, Los Angeles 611 Charles E. Young Dr. E Los Angeles California United States 90095 0000-0003-2432-5419 David S. Eisenberg University of California, Los Angeles 611 Charles E. Young Dr. E Los Angeles California United States 90095 Jiang YX Sawaya MR Abskharon R Ge P Boyer DR National Institutes of Health/National Institute on Aging (NIH/NIA) R01 AG070895 United States National Institutes of Health/National Institute on Aging (NIH/NIA) RF1 AG065407 United States 833.0 10.6019/EMPIAR-13150 EMDB molecule EMD-70224 Abskharon R Jiang YX Sawaya MR Ge P Zhang J Boyer DR Dolinsky JL Pi J Cascio D Guo F Eisenberg DS Structural evidence that RNA contributes to polymorphism of tau fibrils Unaligned multi-frame micrographs of amyloid fibrils of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer’s disease tau fibrils /data micrographs - multiframe TIFF TIFF 2169 30 UNSIGNED BYTE variable variable variable variable

Dose = 1.2 e/A^2/frame Total exposure = 36 e/A^2 Pixel size = 1.077