Convergent and clonotype-specific mutations in the light chain drive affinity maturation of a public antibody targeting a cryptic epitope on S2 of sarbecoviruses

REL 2025-03-04 2026-03-19 2026-03-19 Convergent and clonotype-specific mutations in the light chain drive affinity maturation of a public antibody targeting a cryptic epitope on S2 of sarbecoviruses Goran Bajic Department of Microbiology at Icahn School of Medicine at Mount Sinai 1 Gustave L Levy Pl # 1124 New York New York United States 10029 Goran Bajic Department of Microbiology at Icahn School of Medicine at Mount Sinai 1 Gustave L Levy Pl # 1124 New York New York United States 10029 Bajic GB 1.5 10.6019/EMPIAR-13148 EMDB molecule EMD-48507 Sapse IA Cohn H Yoo DK Tong P Clark JJ Bozarth B Chen Y Srivastava K Singh G Krammer F Simon V Wesemann DR Bajic G Coelho CH Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope Cell reports Cell Rep United States 8 44 2025 English 10.1016/j.celrep.2025.116122 40803328 movies of SARS-CoV2 S2-M15 Fab Complex /data micrographs - multiframe TIFF TIFF 8135 32 UNSIGNED BYTE variable 0.826 variable 0.826