<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-13059" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2025-05-22</depositionDate>
            <releaseDate>2025-12-07</releaseDate>
            <updateDate>2025-12-07</updateDate>
        </keyDates>
        <title>Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-4717-6068</authorORCID>
            <firstName>Minne</firstName>
            <lastName>Jartti</lastName>
            <organization type="academic">Faculty of Medicine and Health Technology, Tampere University</organization>
            <street>Arvo Ylpön katu 34</street>
            <townOrCity>Tampere</townOrCity>
            <stateOrProvince>Pirkanmaa</stateOrProvince>
            <country>Finland</country>
            <postOrZipCode>33520</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-6463-1248</authorORCID>
            <firstName>Minna</firstName>
            <middleName>M</middleName>
            <lastName>Hankaniemi</lastName>
            <organization type="academic">Faculty of Medicine and Health Technology, Tampere University</organization>
            <street>Arvo Ylpön katu 34</street>
            <townOrCity>Tampere</townOrCity>
            <stateOrProvince>Pirkanmaa</stateOrProvince>
            <country>Finland</country>
            <postOrZipCode>33520</postOrZipCode>
        </principalInvestigator>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-7060-5871</authorORCID>
            <firstName>Sarah</firstName>
            <middleName>J</middleName>
            <lastName>Butcher</lastName>
            <organization type="academic">University if Helsinki</organization>
            <street>Viikinkaari 9</street>
            <townOrCity>Helsinki</townOrCity>
            <stateOrProvince>Helsinki</stateOrProvince>
            <country>Finland</country>
            <postOrZipCode>00790</postOrZipCode>
        </principalInvestigator>
        <principalInvestigator private="true">
            <authorORCID>0000-0002-4592-5926</authorORCID>
            <firstName>Varpu</firstName>
            <lastName>Marjomäki</lastName>
            <organization type="academic">University of Jyväskylä</organization>
            <street>Survontie 9</street>
            <townOrCity>Jyväskylä</townOrCity>
            <stateOrProvince>Keski-Suomi</stateOrProvince>
            <country>Finland</country>
            <postOrZipCode>40014</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0002-3546-4572">Soppela S</author>
            <author authorORCID="0000-0002-3335-3369">Plavec Z</author>
            <author authorORCID="0000-0002-3772-7233">Grohn S</author>
            <author authorORCID="0000-0002-4717-6068">Jartti M</author>
            <author authorORCID="0000-0003-3901-6774">Oikarinen S</author>
            <author authorORCID="0000-0003-3981-280X">Laajala M</author>
            <author authorORCID="0000-0002-4592-5926">Marjomaki V</author>
            <author authorORCID="0000-0001-7060-5871">Butcher SJ</author>
            <author authorORCID="0000-0001-6463-1248">Hankaniemi MM</author>
            <author authorORCID="0009-0008-4478-1773">Mustonen I</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>Academy of Finland</fundingBody>
                <code>315950</code>
                <country>Finland</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">1.6</datasetSize>
        <entryDOI>10.6019/EMPIAR-13059</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>virus</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-50497</emdbEntry>
            <emdbEntry>EMD-50498</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0002-3546-4572" order="1">Soppela S</author>
                    <author authorORCID="0000-0002-3335-3369" order="2">Plavec Z</author>
                    <author authorORCID="0000-0002-3772-7233" order="3">Gröhn S</author>
                    <author authorORCID="0009-0008-4478-1773" order="4">Mustonen I</author>
                    <author authorORCID="0000-0002-4717-6068" order="5">Jartti M</author>
                    <author authorORCID="0000-0003-3901-6774" order="6">Oikarinen S</author>
                    <author authorORCID="0000-0003-3981-280X" order="7">Laajala M</author>
                    <author authorORCID="0000-0002-4592-5926" order="8">Marjomäki V</author>
                    <author authorORCID="0000-0001-7060-5871" order="9">Butcher SJ</author>
                    <author authorORCID="0000-0001-6463-1248" order="10">Hankaniemi MM</author>
                    <title>Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines</title>
                    <journal>Scientific reports</journal>
                    <journalAbbreviation>Sci Rep</journalAbbreviation>
                    <country></country>
                    <issue>1</issue>
                    <volume>15</volume>
                    <firstPage>10198</firstPage>
                    <lastPage>10198</lastPage>
                    <year>2025</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41598-025-94656-0</externalReferences>
                    <externalReferences type="pubmed">40133550</externalReferences>
                    <details>Raw data in .tiff format. Collected 40 frames per image at x105,000 nominal magnification resulting in 1.06 Å/per pixel with a total electron exposure dose of 63.368 e-/Å2.</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>CVB1 virus data</name>
        <directory>/data/CVB1-CDC7_virus_data_EMPIAR</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>XML</headerFormat>
        <dataFormat>MRC</dataFormat>
        <numImagesOrTiltSeries>715</numImagesOrTiltSeries>
        <framesPerImage>40</framesPerImage>
        <voxelType>SIGNED 16 BIT INTEGER</voxelType>
        <dimensions>
            <imageWidth>4096</imageWidth>
            <pixelWidth>0.97</pixelWidth>
            <imageHeight>4096</imageHeight>
            <pixelHeight>0.97</pixelHeight>
        </dimensions>
        <details>Micrographs collected at University of Helsinki CryoEM unit in Finland using a FEI Talos Arctica equipped with Falcon III detector and operating at 200 kV. 40 frames per image were collected at 150 000 * nominal magnification resulting in 0.97 Å/pixel with a total dose of 40 e−/Å2. Images were taken between − 0.1 and − 2.8 μm defocus.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
    <imageSet>
        <name>CVB1 VLP data</name>
        <directory>/data/cvb1_vlp_stockholm_rawdata</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>1825</numImagesOrTiltSeries>
        <framesPerImage>40</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>5760</imageWidth>
            <pixelWidth>1.06</pixelWidth>
            <imageHeight>4092</imageHeight>
            <pixelHeight>1.06</pixelHeight>
        </dimensions>
        <details>Micrographs collected at SciLifeLab in Sweden using a Titan Krios equipped with Gatan K3 detector and operating at 300 kV. 40 frames per image were collected at 105 000 * nominal magnification resulting in 1.06 Å/pixel with a total dose of 63.368 e−/Å2. Images were taken between − 0.4 and − 1.6 μm from focus at 0.2 μm defocus increments.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
