REL
2024-10-08
2025-02-27
2025-02-27
EcPKS2 inhibited with Malonyl-CoA
0000-0003-1762-8390
Heidi
Linda
Schubert
Department of Biochemistry; University of Utah
15 N Medical Drive South
Salt Lake City
Utah
United States
84112
0000-0001-6796-7740
Christopher
Hill
University of Utah, Department of Biochemistry
15 N Medical Drive East
Salt Lake City
Utah
United States
84112
Schubert HL
National Science Foundation (NSF, United States)
2203613
United States
4.6
10.6019/EMPIAR-12331
EMDB
molecule
EMD-45907
EMD-45909
EMD-45910
Schubert HL
Li F
Hill CP
Schmidt EW
The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
United States
6
122
2025
English
10.1073/pnas.2419884122
39913209
The micrographs are EcPKS2 bound to Malonyl-CoA at the AT domain and the ACP-pPant is docked at the KS domain with a ordered linker.
Schubert HL
Li F
Hill CP
Schmidt EW
The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly
bioRxiv
2024
10.1101/2024.07.22.604177
EMPIAR-12315
EMPIAR-12314
Unaligned frames for EcPKS2 inhibited with Malonyl-CoA showing the ACP domain at the KS activesite
/data
micrographs - multiframe
TIFF
TIFF
17420
50
1
50
UNSIGNED BYTE
5760
1.06
4092
1.06