REL 2024-03-21 2025-04-24 2025-04-24 cryoEM structure of Gq-coupled MRGPRX4 with fospropofol bound 0000-0003-1822-2384 Jonathan Firoze Fay Univ. of Maryland Baltimore 108 N Greene St Baltimore MD United States 21201 0000-0002-0561-6520 Bryan L Roth UNC Department of Pharmacology 4072 Genetic Medicine Building Chapel Hill NC United States 27514 0000-0002-9750-7718 Xinzhong Dong Johns Hopkins University Baltimore MD United States 21287 Cao C Fay JF Roth BL Chien DC Dong X Limjunyawong N 536.3 10.6019/EMPIAR-11986 EMDB molecule EMD-39542 Chien DC Limjunyawong N Cao C Meixiong J Peng Q Ho CY Fay JF Roth BL Dong X MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model Science translational medicine Sci Transl Med United States 746 16 2024 English 10.1126/scitranslmed.adk8198 38718132
The micrographs are dose weighted motion corrected mrcs from 60 frame movies collected on a 200 keV ThermoFisher Scientific G3 Talos Arctica equipped with a Gatan K3 direct-electron detector (total exposure dose 56.5 e/A^2, 0.88 raw pixel size)
 aligned multi-frame micrographs /data micrographs - single frame MRC MRC 6108 1 UNSIGNED 32 BIT INTEGER 5760 variable 4092 variable
data/*.mrc