REL
2024-02-21
2024-06-11
2024-06-11
CryoEM of Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fibers
0000-0003-2432-5419
David
Eisenberg
Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA
611 Charles E Young Dr E
Los Angeles
California
United States
90095
0000-0003-2432-5419
David
Eisenberg
Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA
611 Charles E Young Dr E
Los Angeles
California
United States
90095
Rosenberg GM
Abskharon R
Boyer DR
Ge P
Sawaya MR
Eisenberg DS
National Institutes of Health/National Institute on Aging (NIH/NIA)
R01AG048120
United States
National Institutes of Health/National Institute on Aging (NIH/NIA)
R01AG07895
United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
U24 GM129541
United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
U24GM116792
United States
National Institutes of Health/Office of the Director
1S10OD018111
United States
National Science Foundation (NSF, United States)
DBI-1338135
United States
National Science Foundation (NSF, United States)
DMR-1548924
United States
1.3
10.6019/EMPIAR-11929
EMDB
molecule
EMD-41195
Rosenberg GM
Abskharon R
Boyer DR
Ge P
Sawaya MR
Eisenberg DS
Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method
PNAS nexus
PNAS Nexus
12
2
2023
English
10.1093/pnasnexus/pgad402
38077690
The micrographs are the average of 40 raw movie frames (accumulating 50 electrons per square Angstrom in a 0.05 second exposure)
Aligned and dose-weighted micrographs of amyloid fibrils formed by the LCD of TFG with the G269V mutation
/data/1.2.3_DW_mrc
micrographs - single frame
MRC
MRC
15192
1
32 BIT FLOAT
5760
variable
4092
variable