<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-11865" schemaVersion="0.64" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2024-01-25</depositionDate>
            <releaseDate>2024-02-06</releaseDate>
            <updateDate>2024-02-06</updateDate>
        </keyDates>
        <title>CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-0848-5335</authorORCID>
            <firstName>Grigore</firstName>
            <lastName>Pintilie</lastName>
            <organization type="academic">Department of Bioengineering, Stanford University</organization>
            <townOrCity>Stanford</townOrCity>
            <country>United States</country>
            <postOrZipCode>L6A 1V3</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-7787-306X</authorORCID>
            <firstName>Merritt</firstName>
            <lastName>Maduke</lastName>
            <organization type="academic">Department of Molecular and Cellular Physiology, Stanford University</organization>
            <townOrCity>Stanford</townOrCity>
            <country>United States</country>
            <postOrZipCode>94305</postOrZipCode>
        </principalInvestigator>
        <principalInvestigator private="true">
            <authorORCID>0000-0002-8910-3078</authorORCID>
            <firstName>Wah</firstName>
            <lastName>Chiu</lastName>
            <organization type="academic">Department of Bioengineering and Department of Microbiology and Immunology, Stanford University</organization>
            <townOrCity>Stanford</townOrCity>
            <country>United States</country>
            <postOrZipCode>94305</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0003-3895-0469">Xu M</author>
            <author authorORCID="0000-0002-0848-5335">Pintilie G</author>
            <author authorORCID="0000-0001-5683-8695">Liu Y</author>
            <author authorORCID="0000-0002-8910-3078">Chiu W</author>
            <author authorORCID="0000-0001-7787-306X">Maduke M</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>National Institutes of Health (NIH)</fundingBody>
                <code>R21NS125767</code>
                <country>United States</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">1.2</datasetSize>
        <entryDOI>10.6019/EMPIAR-11865</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-41127</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="false" preprint="false">
                    <author authorORCID="0000-0003-3895-0469" order="1">Xu M</author>
                    <author authorORCID="0000-0002-0848-5335" order="2">Pintilie G</author>
                    <author authorORCID="0000-0001-5683-8695" order="3">Liu Y</author>
                    <author authorORCID="0000-0002-8910-3078" order="4">Chiu W</author>
                    <author authorORCID="0000-0001-7787-306X" order="5">Maduke M</author>
                    <title>CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism</title>
                    <journal>eLife</journal>
                    <journalAbbreviation></journalAbbreviation>
                    <country>United States</country>
                    <year>2023</year>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>picked particles for CLC2 trans-membrane domain</name>
        <directory>/data</directory>
        <category>picked particles - multiframe - unprocessed</category>
        <headerFormat>MRC</headerFormat>
        <dataFormat>MRC</dataFormat>
        <numImagesOrTiltSeries>11404</numImagesOrTiltSeries>
        <framesPerImage>446</framesPerImage>
        <frameRange>
            <frameRangeMin>0</frameRangeMin>
            <frameRangeMax>445</frameRangeMax>
        </frameRange>
        <voxelType>32 BIT FLOAT</voxelType>
        <dimensions>
            <imageWidth>256</imageWidth>
            <pixelWidth>0.946</pixelWidth>
            <imageHeight>256</imageHeight>
            <pixelHeight>variable</pixelHeight>
        </dimensions>
        <details>Picked particles extracted from fractionated data</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern>data/CLC-2/*_Fractions_patch_aligned_doseweighted_particles.mrc</pickedParticlesFilePattern>
        <pickedParticlesDirectory>data/CLC-2</pickedParticlesDirectory>
    </imageSet>
</entry>
