<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-11680" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2023-08-04</depositionDate>
            <releaseDate>2025-07-16</releaseDate>
            <updateDate>2025-07-16</updateDate>
        </keyDates>
        <title>Single particle cryo-EM dataset of sarkosyl-insoluble fraction from tg-SwDI mouse mouse brain tissue containing amyloid-beta fibrils</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0003-1803-5431</authorORCID>
            <firstName>Gunnar</firstName>
            <middleName>F</middleName>
            <lastName>Schröder</lastName>
            <organization type="academic">Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany</organization>
            <street>Wilhelm-Johnen-Straße</street>
            <townOrCity>Jülich</townOrCity>
            <stateOrProvince>North Rhine-Westphalia</stateOrProvince>
            <country>Germany</country>
            <postOrZipCode>52428</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0003-1803-5431</authorORCID>
            <firstName>Gunnar</firstName>
            <middleName>F</middleName>
            <lastName>Schröder</lastName>
            <organization type="academic">Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany</organization>
            <street>Wilhelm-Johnen-Straße</street>
            <townOrCity>Jülich</townOrCity>
            <stateOrProvince>North Rhine-Westphalia</stateOrProvince>
            <country>Germany</country>
            <postOrZipCode>52428</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0001-7443-917X">Zielinski M</author>
            <author authorORCID="0000-0001-8379-4827">Peralta Reyes FS</author>
            <author authorORCID="0000-0001-7065-5027">Gremer L</author>
            <author authorORCID="0000-0002-7228-2700">Schemmert S</author>
            <author authorORCID="0000-0002-7877-0262">Frieg B</author>
            <author authorORCID="0000-0002-8481-6298">Schäfer LU</author>
            <author authorORCID="0000-0002-6725-0755">Willuweit A</author>
            <author authorORCID="0000-0002-3997-1117">Donner L</author>
            <author authorORCID="0000-0002-3234-9341">Elvers M</author>
            <author authorORCID="0000-0002-8362-1042">Nilsson LNG</author>
            <author authorORCID="0000-0002-8196-4041">Syvänen S</author>
            <author authorORCID="0000-0002-9430-3859">Sehlin D</author>
            <author authorORCID="0000-0001-5466-8370">Ingelsson M</author>
            <author authorORCID="0000-0002-0065-7366">Willbold D</author>
            <author authorORCID="0000-0003-1803-5431">Schröder GF</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>German Federal Ministry for Education and Research</fundingBody>
                <code>16LW028</code>
                <country>Germany</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">11.2</datasetSize>
        <entryDOI>10.6019/EMPIAR-11680</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-16959</emdbEntry>
            <emdbEntry>EMD-16957</emdbEntry>
            <emdbEntry>EMD-16961</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0001-7443-917X" order="1">Zielinski M</author>
                    <author authorORCID="0000-0001-8379-4827" order="2">Peralta Reyes FS</author>
                    <author authorORCID="0000-0001-7065-5027" order="3">Gremer L</author>
                    <author order="4">Schemmert S</author>
                    <author authorORCID="0000-0002-7877-0262" order="5">Frieg B</author>
                    <author order="6">Schäfer LU</author>
                    <author authorORCID="0000-0002-6725-0755" order="7">Willuweit A</author>
                    <author order="8">Donner L</author>
                    <author order="9">Elvers M</author>
                    <author authorORCID="0000-0002-8362-1042" order="10">Nilsson LNG</author>
                    <author authorORCID="0000-0002-8196-4041" order="11">Syvänen S</author>
                    <author authorORCID="0000-0002-9430-3859" order="12">Sehlin D</author>
                    <author order="13">Ingelsson M</author>
                    <author authorORCID="0000-0002-0065-7366" order="14">Willbold D</author>
                    <author authorORCID="0000-0003-1803-5431" order="15">Schröder GF</author>
                    <title>Cryo-EM of Aβ fibrils from mouse models find tg-APP&lt;sub&gt;ArcSwe&lt;/sub&gt; fibrils resemble those found in patients with sporadic Alzheimer's disease</title>
                    <journal>Nature neuroscience</journal>
                    <journalAbbreviation>Nat Neurosci</journalAbbreviation>
                    <country>United Kingdom</country>
                    <issue>12</issue>
                    <volume>26</volume>
                    <firstPage>2073</firstPage>
                    <lastPage>2080</lastPage>
                    <year>2023</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41593-023-01484-4</externalReferences>
                    <externalReferences type="pubmed">37973869</externalReferences>
                    <details>The files are unaligned multi-frame movies. The data was collected in EER format with 700 camera frames (total dose of 40.1 electrons per squared Angstrom in a 2.91s exposure).</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Unaligned multi-frame micrographs of amyloid fibrils extracted from the tg-SwDI mouse model</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>EER</headerFormat>
        <dataFormat>EER</dataFormat>
        <numImagesOrTiltSeries>25662</numImagesOrTiltSeries>
        <framesPerImage>700</framesPerImage>
        <voxelType>BIT</voxelType>
        <dimensions>
            <imageWidth>4096</imageWidth>
            <pixelWidth>0.808</pixelWidth>
            <imageHeight>4096</imageHeight>
            <pixelHeight>0.808</pixelHeight>
        </dimensions>
        <details>The files are unaligned multi-frame movies. The data was collected in EER format with 700 camera frames (total dose of 40.1 electrons per squared Angstrom in a 2.91s exposure).</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
