REL 2023-06-13 2024-06-13 2024-06-13 Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex 0000-0002-9948-680X Remi Jo Ruedas Sanofi, Integrated Drug Discovery 13, Quai Jules Guesdes - BP 14 Vitry-sur-seine Val-de-Marne France 94403 0000-0002-0921-6727 Stephane Bressanelli CNRS - Institute for Integrative Biology of the Cell (I2BC) 1 avenue de la terrasse Gif sur yvette Essonne France 91198 Ruedas R Vuillemot R Tubiana T Winter JM Pieri L Arteni AA Samson C Jonic S Mathieu M Bressanelli S 207.2 10.6019/EMPIAR-11665 EMDB molecule EMD-17993 EMD-18188 EMD-18189 EMD-18190 Ruedas R Vuillemot R Tubiana T Winter JM Pieri L Arteni AA Samson C Jonic S Mathieu M Bressanelli S Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex Journal of structural biology J Struct Biol 2 216 2024 English 10.1016/j.jsb.2024.108095 38723875 Aligned particles images of the flexible HER2-Trastuzumab-Pertuzumab ternary complex /data/extract picked particles - multiframe - processed MRC MRCS 708609 1 32 BIT FLOAT 280 1.16 280 1.16
This the particle stack for the global reconstruction of the flexible HER2-Trastuzumab-Pertuzumab ternary complex. It allows reconstruction to an overall resolution < 3.3 A. The data sign is +1, white particle on dark background. The accompanying star file is exported from the last round of global refinement in cryoSPARC v. 4.1.2, with all the CTF parameters recorded. The dataset displays considerable continuous conformational variability.
data/J503_csparc2star-particles.star data/extract