REL
2023-03-16
2025-03-21
2025-03-21
Unaligned cryo-EM micrographs of HCN4 channel bound to Ivabradine
0000-0003-3287-9024
Antonio
Chaves-Sanjuan
Department of Biosciences, University of Milan
Milan
Italy
20133
0000-0002-1860-406X
Anna
Moroni
Department of Biosciences, University of Milan
Milan
Italy
20133
0000-0001-5035-5174
Andrea
Saponaro
Department of Biosciences, University of Milan
Milan
Italy
20133
Saponaro A
Chaves-Sanjuan A
Sharifzadeh AS
Clarke OB
Marabelli C
Bolognesi M
Thiel G
Moroni A
Leducq Foundation
TNE19CVD03
France
Fondazione CARIPLO
2018-0231
Italy
European Research Council (ERC)
ERC Advanced grant noMAGIC 695078
Italy
National Institutes of Health (NIH)
NIH grants R01-NS109366
United States
National Institutes of Health (NIH)
P41-GM116799
United States
National Institutes of Health (NIH)
R01-GM107462
United States
9.3
10.6019/EMPIAR-11470
EMDB
molecule
EMD-16860
Saponaro A
Krumbach JH
Chaves-Sanjuan A
Sharifzadeh AS
Porro A
Castelli R
Hamacher K
Bolognesi M
DiFrancesco D
Clarke OB
Thiel G
Moroni A
Chaves-Sanjuan A
Structural determinants of ivabradine block of the open pore of HCN4
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
27
121
2024
English
10.1073/pnas.2402259121
38917012
The micrographs are unaligned 40-frames movies with a total dose of 40e/A2. collected in super-resolution mode. Gain reference files are in the folder containing the micrographs.
Unaligned multi-frame micrographs of HCN4 channel bound to Ivabradine
/data
micrographs - multiframe
TIFF
TIFF
31670
40
UNSIGNED BYTE
11520
0.42
8184
0.42
The micrographs comes from two different data collection sessions and they are divided in two separated folders, each containing their own gain-reference file. The micrographs were recorded in super-resolution mode.