REL
2022-08-30
2022-10-31
2022-10-31
cryoEM structure of Gq-coupled MRGPRX1 with Compound-16
0000-0003-1822-2384
Jonathan
Firoze
Fay
UNC at Chapel Hill
Thurston-Bowles Building Room 6107
Chapel Hill
NC
United States
27599
0000-0002-0561-6520
Bryan
L
Roth
UNC Department of Pharmacology
4072 Genetic Medicine Building
Chapel Hill
NC
United States
27514
Liu Y
Cao C
Huang XP
Gumpper RH
Rachman MM
Shih SL
Krumm BE
Zhang S
Shoichet BK
Fay JF
Roth BL
288.1
10.6019/EMPIAR-11191
EMDB
molecule
EMD-27753
EMD-27752
EMD-27754
Liu Y
Cao C
Huang XP
Gumpper RH
Rachman MM
Shih SL
Krumm BE
Zhang S
Shoichet BK
Fay JF
Roth BL
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
Nature chemical biology
Nat Chem Biol
2022
English
10.1038/s41589-022-01173-6
36302898
The micrographs are motion corrected 60 frame movies collected on a 200 kV ThermoFisher Scientific G3 Talos Arctica equipped with a Gatan K3 direct-electron detector (total exposure dose 43.8 e/A^2, 0.88 raw pixel size)
Aligned multi-frame micrographs
/data
micrographs - single frame
MRC
MRC
3281
1
32 BIT FLOAT
5760
0.88
4092
0.88
The micrographs are dose weighted motion corrected with a total electron exposure of 43.8e/A2