<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-10965" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2022-02-22</depositionDate>
            <releaseDate>2022-03-15</releaseDate>
            <updateDate>2022-03-15</updateDate>
        </keyDates>
        <title>Cryo-EM structure of human RNA polymerase I in elongation state</title>
        <correspondingAuthor>
            <authorORCID>0000-0003-2176-8337</authorORCID>
            <firstName>Christoph</firstName>
            <middleName>W</middleName>
            <lastName>Müller</lastName>
            <organization type="academic">European Molecular Biology Laboratory (EMBL)</organization>
            <street>Meyerhofstraße 1</street>
            <townOrCity>Heidelberg</townOrCity>
            <stateOrProvince>Baden-Württemberg</stateOrProvince>
            <country>Germany</country>
            <postOrZipCode>69117</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator>
            <authorORCID>0000-0003-2176-8337</authorORCID>
            <firstName>Christoph</firstName>
            <middleName>W</middleName>
            <lastName>Müller</lastName>
            <organization type="academic">European Molecular Biology Laboratory (EMBL)</organization>
            <street>Meyerhofstraße 1</street>
            <townOrCity>Heidelberg</townOrCity>
            <stateOrProvince>Baden-Württemberg</stateOrProvince>
            <country>Germany</country>
            <postOrZipCode>69117</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0002-9763-1815">Misiaszek AD</author>
            <author authorORCID="0000-0003-3442-5448">Girbig M</author>
            <author authorORCID="0000-0003-2176-8337">Müller CW</author>
        </authorsList>
        <datasetSize units="TB">1.8</datasetSize>
        <entryDOI>10.6019/EMPIAR-10965</entryDOI>
        <experimentType>EMDB</experimentType>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-12795</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0002-9763-1815" order="1">Misiaszek AD</author>
                    <author authorORCID="0000-0003-3442-5448" order="2">Girbig M</author>
                    <author authorORCID="0000-0003-1948-3922" order="3">Grötsch H</author>
                    <author authorORCID="0000-0003-0816-0861" order="4">Baudin F</author>
                    <author authorORCID="0000-0001-8886-2972" order="5">Murciano B</author>
                    <author authorORCID="0000-0003-1549-3162" order="6">Lafita A</author>
                    <author authorORCID="0000-0003-2176-8337" order="7">Müller CW</author>
                    <title>Cryo-EM structures of human RNA polymerase I</title>
                    <journal>Nature structural &amp; molecular biology</journal>
                    <journalAbbreviation>Nat Struct Mol Biol</journalAbbreviation>
                    <country>Germany</country>
                    <issue>12</issue>
                    <volume>28</volume>
                    <firstPage>997</firstPage>
                    <lastPage>1008</lastPage>
                    <year>2021</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41594-021-00693-4</externalReferences>
                    <externalReferences type="pubmed">34887565</externalReferences>
                    <details>Raw, multi-frame micrographs (38-frames), total electron dose 51 e/A2</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Unaligned multi-frame micrographs of human RNA polymerase I in elongating state</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>10053</numImagesOrTiltSeries>
        <framesPerImage>38</framesPerImage>
        <frameRange>
            <frameRangeMin>1</frameRangeMin>
            <frameRangeMax>38</frameRangeMax>
        </frameRange>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>5760</imageWidth>
            <pixelWidth>0.822</pixelWidth>
            <imageHeight>4092</imageHeight>
            <pixelHeight>0.822</pixelHeight>
        </dimensions>
        <details>Unaligned multi-frame (38 frames) micrographs acquired over 1.52s with 1.77 e/Å2/frame over 38 frames giving total electron dose of 51 e/Å2 with defocus range of 1.0–2.5 μm.Gain reference is in CountRef_200820_Krios_Pol1_DNA_00001_1-1.mrc file.</details>
        <segmentationList/>
        <micrographsFilePattern>data/200820_Krios_Pol1_DNA_*.tif</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
