REL
2021-03-07
2021-11-12
2022-02-25
Disease variant M854K MDA5-dsRNA filaments in complex with ADP-AlF4
0000-0002-6084-0429
Yorgo
Modis
Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge
Cambridgeshire
United Kingdom
CB2 0QH
0000-0002-6084-0429
Yorgo
Modis
Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge
Cambridgeshire
United Kingdom
CB2 0QH
Yu Q
Modis Y
2.5
10.6019/EMPIAR-10664
EMDB
EMD-12288
EMD-12294
Yu Q
Herrero Del Valle A
Singh R
Modis Y
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
Nature communications
Nat Commun
United States
1
12
2021
English
10.1038/s41467-021-27062-5
34795277
Raw movies containing 60 frames per movie (accumulating 29.6 electrons per square Angstrom, over 60 s).
Yu Q
Herrero Del Valle A
Singh R
Modis Y
MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
bioRxiv
United States
2021
English
10.1101/2021.02.01.429133
Raw movies containing 60 frames per movie (accumulating 29.6 electrons per square Angstrom, over 60 s).
Unaligned multi-frame micrographs of MDA5 variant M854K bound to dsRNA and ADP-ALF4
/data
micrographs - multiframe
TIFF
TIFF
2177
60
SIGNED 16 BIT INTEGER
4096
1.084
4096
1.084
Particle positions used for final reconstruction are in corresponding *particles.star files.
Each raw movie contain 60 unaligned frames (accumulating 29.6 electrons per square Å in a 60s exposure).
data/FoilHole_2*_Fractions.tif
data/coordinate/*particles.star
data/coordinate