<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-10662" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2021-01-21</depositionDate>
            <releaseDate>2021-04-14</releaseDate>
            <updateDate>2021-04-14</updateDate>
        </keyDates>
        <title>SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs</title>
        <correspondingAuthor>
            <authorORCID>0000-0001-6768-3406</authorORCID>
            <firstName>Stephen</firstName>
            <middleName>Graf</middleName>
            <lastName>Brohawn</lastName>
            <organization type="academic">UC Berkeley</organization>
            <townOrCity>Berkeley</townOrCity>
            <stateOrProvince>California</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>94720</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator>
            <authorORCID>0000-0001-6768-3406</authorORCID>
            <firstName>Stephen</firstName>
            <middleName>Graf</middleName>
            <lastName>Brohawn</lastName>
            <organization type="academic">UC Berkeley</organization>
            <townOrCity>Berkeley</townOrCity>
            <stateOrProvince>California</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>94720</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0001-8529-9045">Kern DM</author>
            <author>Gerber EE</author>
            <author authorORCID="0000-0001-6768-3406">Brohawn SG</author>
        </authorsList>
        <datasetSize units="TB">2.7</datasetSize>
        <entryDOI>10.6019/EMPIAR-10662</entryDOI>
        <experimentType>EMDB</experimentType>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-23614</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="true">
                    <author order="1">Gunasekar SK</author>
                    <author order="2">Xie L</author>
                    <author order="3">Chheda PR</author>
                    <author order="4">Kang C</author>
                    <author authorORCID="0000-0001-8529-9045" order="5">Kern DM</author>
                    <author order="6">My-Ta C</author>
                    <author order="7">Kumar A</author>
                    <author order="8">Maurer J</author>
                    <author order="9">Gerber EE</author>
                    <author order="10">Grzesik WJ</author>
                    <author order="11">Elliot-Hudson M</author>
                    <author order="12">Zhang Y</author>
                    <author order="13">Kulkarni CA</author>
                    <author order="14">Samuel I</author>
                    <author order="15">Smith JK</author>
                    <author order="16">Nau P</author>
                    <author order="17">Imai Y</author>
                    <author order="18">Sheldon RD</author>
                    <author order="19">Taylor EB</author>
                    <author order="20">Lerner DJ</author>
                    <author order="21">Norris AW</author>
                    <author authorORCID="0000-0001-6768-3406" order="22">Brohawn SG</author>
                    <author order="23">Kerns R</author>
                    <author order="24">Sah R</author>
                    <title>Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes</title>
                    <journal>bioRxiv</journal>
                    <journalAbbreviation></journalAbbreviation>
                    <country></country>
                    <year>2021</year>
                    <externalReferences type="doi">10.1101/2021.02.28.432901</externalReferences>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>LRRC8A-SN-407 in MSP1E3D1 nanodiscs</name>
        <directory>/data/SN407_frames</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>3576</numImagesOrTiltSeries>
        <framesPerImage>50</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.5685</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.5685</pixelHeight>
        </dimensions>
        <details>Gain reference is included in the "SN407_frames" folder with the movies. Dose per frame= 1.0318 e/A2. The SN407_particles folder contains both the whole set of polished particles and two Refine3D data files (pointing to a classed set of polished particles) for the SN-407 poses.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
