Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses

REL 2018-07-12 2019-08-07 2021-09-01 Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses 0000-0003-3378-0683 James Alexander Geraets Institute of Biotechnology, University of Helsinki P.O. Box 56 University of Helsinki Finland 00014 0000-0001-7060-5871 Sarah Jane Butcher Faculty of Biological and Environmental Sciences and Institute of Biotechnology, University of Helsinki P.O. Box 56 University of Helsinki Finland 12 Geraets JA Flatt JW Domanska A Butcher SJ 2.2 10.6019/EMPIAR-10199 EMDB EMD-0103 Abdelnabi R Geraets JA Ma Y Mirabelli C Flatt JW Domanska A Delang L Jochmans D Kumar TA Jayaprakash V Sinha BN Leyssen P Butcher SJ Neyts J A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses PLoS biology PLoS Biol. 6 17 2019 English 10.1371/journal.pbio.3000281 31185007 Unaligned multi-frame micrographs of CVB3 in complex with a small molecular inhibitor /data micrographs - single frame MRC MRC 2120 20 1 20 32 BIT FLOAT 3838 1.048 3710 1.048

These data are unaligned frames (20 dose fractions) collected on a K2 Summit in counting mode at Diamond Light Source, U.K. Total electron dose was ~47e-/Å². Micrographs are grouped by the GridSquare in which they were collected. Also included are the particle coordinates for 10173 particles after 2D classification (Relion particle coordinate STAR file format).